Ukrainica Bioorganica Acta www.bioorganica.org.ua

RESEARCH ARTICLE

Paper title (not more than 140 characters including spaces).
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Introduction

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Results and Discussion

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Received: Revised: Accepted: Published online:	00.00.202X 00.00.202X 00.00.202X 00.00.202X
Corresponding author. Tel.: +XXX-XX-XXX-XXXX; e-mail: author@university.edu (Surname of author) ORCID: 0000-0000-0000-0000

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© Author1 et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Figures and schemes

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Table 1. Table title (must fit in one line for double column tables).

Name	Sequence a	Property 1, %	Property 2, %	Property 3, nm	Relative Activity	Property 4, °C	Reference
1	QWERTYIP	yes	-	1.1	77	772	[1]
2	TASDFGHKL	N/A	-	2.3	7	879	[2]
3b	CVNM	-	187	7.3	55	878
4	PEPTIDE	-	22	11.0	5	975

If you need to paste a double column table, figure or scheme use section breaks before and after it or simply copy and modify this table used as an example (note that one of the section breaks is on the previous page). Try to put them only on top and bottom of pages. Please try not to use not more than one double-column objet per page. Tables should fit in one journal page.

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Table 2. Table title (must fit in one or two lines for single column tables) a.

R	Conditions	Yield, %	Property 2, °C
Cl	THF, -18°C, 3h	1.1	772
Me	THF, -18°C, 7h	2.3	879
NMe2	THF, -18°C, 33m	7.3	878
Ph	THF, -18°C, 2d	11.0	975
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Conclusions

Please discuss the role of your work and add necessary comparisons with already known findings.

Experimental section

General section (All reagents were Purchased from ….)

Synthesis

1.1. IUPAC name AND/OR abbreviation (1).

400 mg (0.57 mmol) of 2a were mixed with DCM (10 ml), then TFA (500 µl) and H2O (50 μl) were added. Reaction mixture was stirred at room temperature for 48 h. Then the solvents were evaporated, and the precipitate was dried in vacuum. The residue was dissolved in 3 ml of DCM. Compound 1 was precipitated by addition of 75 ml of diethyl ether and was carefully filtered, yielding red crystals. Yield: 29 mg, 84 %; TLC (hexane/EtOAc 4:6, KMnO4-stain) Rf 0.28; [α]D 20 -21.7 (c 0.60, CHCl3);
1H NMR (500 MHz, CDCl3) δ 7.30-7.27 (m, 2H), 7.19-7.17 (m, 3H), 4.44 (dt, J 47.4, 6.2 Hz, 2H), 2.61 (t, J 7.5 Hz, 2H), 1.74-1.59 (m, 4H), 1.42-1.33 (m, 8H); 13C NMR (125 MHz, CDCl3) δ 142.8, 128.4, 128.2, 125.6, 84.2 (d,
JC-F 162.8 Hz), 35.9, 31.5, 30.4 (d, JC-F 19.1 Hz), 29.4, 29.2, 29.2, 25.1 (d, JC-F 5.5 Hz); 19F NMR (282 MHz, CDCl3) δ
-218.02 (tt, J 48.1, 24.9 Hz); IR (KBr) ν 3034, 1718, 1627, 1379, 1250, 1046, 835, 754, 728. HRMS (ESI) m/z Сalcd. for C29H37O6N4S2 (M+H)+ 601.2149. Found 601.2144.

Activity studies

Two-column reaction scheme Example.

Scheme 2. An example of a two-column reaction scheme. Please insert schemes as ChemDraw objects (not simple images). Use ACS document 1996 drawing style. If you need to paste a double column scheme into your paper you can simply copy this scheme including section breaks before and after it. Please do not use more than on double column scheme per page.

Notes

Acknowledgments and finances. Please acknowledge people and organizations who financed the work or helped you with it but did not contribute to its scientific part (for example: The work was supported by Ukrainian Science foundation, Grant 123-456, Author1 was a recipient of Marie Curie postdoctoral fellowship. We also thank Prof. XX (University of XY) for providing samples of chromosomes).

The authors declare no conflict of interest. Please change this text if one or more of the authors hold patent(s) for any of compounds or work for a company that sells any of compounds mentioned in the paper.

Author contributions. Author 1: Synthesis of compounds, Investigation, Formal analysis, writing experimental section, editing. Author 2: Investigation, Formal analysis, Writing most of the manuscript. Author 3: Conceptualization, Supervision, Writing - review & editing. Author 4: X-ray analysis. This chapter is obligatory only for papers with 5 or more authors.

Supporting information

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References

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Joule, J. A.; Mills, K. Heterocyclic Chemistry, fifth ed., Wiley Blackwell: New Jersey, 2010.

Kafarski, P.; Lejczak, B. In Aminophosphonic and Aminophosphinic; Acids: Chemistry and Biological Activity; Kukhar, V. P., Hudson, H. R., Eds.; John Wiley & Sons: Chichester, UK, 2000; pp 407-442.

Gerus, I. I.; Balabon, O. A.; Pazenok, S. V.; Lui, N.; Kondratov, I. S.; Tarasenko, K. V.; Shaitanova, E. N.; Ivasyshyn, V. E.; Kukhar, V. P. Eur. J. Org. Chem. 2018, 2018, 3853-3861.

Radchenko, I. V; Kostyuchenko, N. V; Naidenova, I. Yu; Batrak, G. N; Poda, G. I; Mogilevich, S. E; Kibirev, V. K; Luik, A. I. Ukr. Biokhim. Zh. (1978) 1993, 65, 37-40 (in Ukrainian).

Grygorenko, О. О. Extended abstract of PhD dissertation (Chemistry), Kyiv, 1998. (in Ukrainian).

Thompson, A. Ph.D. Dissertation, Clemson University, 2007.

US Patent No 7375249 B2. Process for the synthesis of enantiomeric indanylamine derivatives / Boulton, L. T.; Lennon, I. C; Bahar, E. Patent appl. No 11/358995 21.02.2006. Publ. 20.05.2008.

Article Title in Ukrainian (Назва статті українською)

Ініціали. Прізвище автора 11, Ініціали. Прізвище автора2*, ….

1Університет 1, адреса.

2Університет 2, адреса.

Резюме: Abstract in Ukrainian (Абстракт українською).

Ключові слова: від 3 to 5 слів, відокремлених крапкою з комою.