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Ukr. Bioorg. Acta 2020, Vol. 15, N2, 22-26.

DOI: hpps://doi.org/10.15407/bioorganica2020.02.022

Condition-based switching the multicomponent reactions of 5-amino-3-(methylthio)-1,2,4-triazole, aromatic aldehydes, and pyruvic acid

Yana I. Sakhno1, Maksym V. Mykhailenko1,2, Maksim A. Kolosov2, Elena H. Shvets2, Vladimir I. Musatov1, Natalia V. Chorna1, Sergey M. Desenko1 and Valentyn A. Chebanov1,2*

1 State Scientific Institution “Institute for Single Crystals” of the NAS of Ukraine, 60 Nauky Ave., Kharkiv, 61072, Ukraine
tel.: +380-67-576-6227; e-mail: chebanov@isc.kh.ua
2 V. N. Karazin Kharkiv National University, 4 Svobody Sq., Kharkiv, 61077, Ukraine

The multicomponent reactions of 5-amino-3-methylthio-1,2,4-triazole with aromatic aldehydes and pyruvic acid were studied using conventional thermal heating and ultrasonic activation at room temperature. Under conventional heating, dihydrotriazolopyrimidine derivatives were formed in both two- and three-component treatments. In the case of ultrasonic activation, the multicomponent reaction led to the formation of 7-hydroxytetrahydrotriazolopyrimidines.

5-Amino-3-(methylthio)-1,2,4-triazole; multicomponent reaction; ultrasonication; pyruvic acid; heterocyclization.

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